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The uric acid to high density lipoprotein cholesterol ratio as a new indicator for predicting coronary slow flow
Gui-Ming Zhang1, Xiao-Yang Pei1, Ting-Fang Ye2
1Department of Cardiology, Shenzhen Luohu Hospital Group Luohu People's Hospital (Third Affiliated Hospital of Shenzhen University), Shenzhen, China.
Insights
The uric acid to high density lipoprotein cholesterol ratio (UHR) is a novel predictor for coronary slow flow phenomenon (CSFP). UHR shows a superior predictive value for CSFP than individual markers, aiding in risk stratification.
Area of Science:
- Cardiology
- Biomarkers
- Coronary Artery Disease
Background:
- The uric acid to high density lipoprotein cholesterol ratio (UHR) is linked to inflammation and insulin resistance.
- UHR's association with coronary artery disease is established, but its role in coronary slow flow phenomenon (CSFP) is unknown.
Purpose of the Study:
- To investigate the relationship between UHR and the occurrence of CSFP.
- To evaluate UHR's predictive value for CSFP compared to individual components.
Main Methods:
- 1602 patients undergoing coronary angiography for chest pain were analyzed.
- 91 patients diagnosed with CSFP were compared to 182 matched controls.
- Statistical analysis explored the association between UHR and CSFP.
Main Results:
- CSFP patients exhibited higher BMI, uric acid, and UHR, with lower HDL-C.
- UHR was identified as an independent predictor of CSFP.
- UHR demonstrated a greater predictive capability for CSFP than uric acid or HDL-C alone.
Conclusions:
- UHR is positively correlated with CSFP.
- UHR serves as a novel indicator with superior predictive value for CSFP.
- UHR can be utilized for predicting and risk-stratifying CSFP.
Background:
The uric acid to high density lipoprotein cholesterol ratio (UHR) was suggested as a parameter for assessing inflammatory status and insulin resistance, which was closely correlated with coronary artery disease. Nevertheless, the relationship between UHR and coronary slow flow phenomenon (CSFP) remains unexplored.
Methods:
We consecutively recruited 1602 patients receiving coronary angiography due to chest pain and found normal coronary arteries, of whom 91 patients developed CSFP (CSFP group, n = 91). A 1:2 sex-and-age matched patients were selected as controls (control group, n = 182). The relationships between UHR and CSFP were explored.
Results:
We observed that CSFP patients had an increased body mass index (BMI), uric acid and UHR, while a lower lever of high-density lipoprotein cholesterol (HDL-C) (p < 0.05). In the CSFP patients, right coronary arteries was the most frequently affected vessels, while three coronary arteries involved in CSFP was mostly common seen. We observed that UHR was an independent predictor for CSFP (p < 0.05). In addition, UHR suggested a higher predictive value than uric acid and HDL-C.
Conclusion:
UHR was positively correlated with CSFP. As a novel indicator, UHR provided a superior predictive value for the occurrence of CSFP than single indicators. We suggested that UHR could be used a indicator for the prediction as well as and risk stratification for CSFP patients.
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