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Related Concept Videos

Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

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Related Experiment Video

Updated: May 13, 2026

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
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Sacral florid reactive periostitis: a case report.

Xianwei Han1, Huijun Jiang2, Ming Chen2

  • 1Department of Orthopedic Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shanxi, China. hanxianwei789@163.com.

Journal of Medical Case Reports
|November 29, 2025
PubMed
Summary
This summary is machine-generated.

Florid reactive periostitis, a rare bone lesion, was diagnosed in the sacrum of a young female. Conservative treatment effectively resolved symptoms, expanding the known locations for this benign condition.

Keywords:
DiagnosisFibro-osseous pseudotumorFlorid reactive periostitisPathologySacrum

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Last Updated: May 13, 2026

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Area of Science:

  • Orthopedic Oncology
  • Skeletal Radiology
  • Surgical Pathology

Background:

  • Florid reactive periostitis is a rare benign periosteal lesion typically affecting the hands and feet.
  • Involvement of the sacrum is exceptionally rare, presenting diagnostic challenges.

Purpose of the Study:

  • To report a unique case of florid reactive periostitis in the sacrum.
  • To discuss diagnostic considerations and treatment outcomes for this rare presentation.

Main Methods:

  • A 12-year-old female with sacrococcygeal pain underwent CT/MRI, histopathology, immunohistochemistry, and USP6 FISH testing.
  • Imaging findings were initially suspicious for malignancy.
  • Pathological examination confirmed florid reactive periostitis.

Main Results:

  • Imaging showed expansive bone destruction with periosteal reaction and soft tissue edema.
  • Histopathology revealed fibroblastic proliferation, osteoid formation, and chronic inflammation.
  • Conservative management with NSAIDs and immobilization led to symptom resolution and radiographic improvement.

Conclusions:

  • This case expands the anatomical distribution of florid reactive periostitis to the sacrum.
  • Multidisciplinary correlation is crucial to differentiate from malignant lesions.
  • Conservative management can be effective for symptomatic sacral florid reactive periostitis.