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Bimetallic Nanozymes: Structure-Activity, Regulatory Strategies, and Adaptive Applications.

Xi Sun1, Jiaqi Cui1, Xiao Tan1

  • 1School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao, 266520, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)
|November 29, 2025
PubMed
Summary
This summary is machine-generated.

Bimetallic nanozymes, artificial enzymes with two metal sites, offer enhanced catalysis and stability. This review categorizes their structures, activities, and applications in medicine and environmental science.

Keywords:
applicationsbimetallic nanozymescatalytic activityregulatory mechanismsreview

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Catalysis

Background:

  • Bimetallic nanozymes are artificial enzymes with dual metal active sites.
  • They exhibit superior catalytic performance, stability, and reactivity over monometallic nanozymes.
  • Synergistic interactions between metals enhance catalytic efficiency and selectivity.

Purpose of the Study:

  • To systematically review and categorize bimetallic nanozymes.
  • To elucidate their enzyme-like activities and regulatory strategies.
  • To examine their applications in biomedical, environmental, and food safety fields.

Main Methods:

  • Categorization of bimetallic nanozymes into five structural types: single-atom, cluster, nanoparticle, MOF-based, and composite systems.
  • Elucidation of enzyme-like activities (oxidase, peroxidase, catalase, hydrolase).
  • Discussion of advanced strategies for activity regulation (metal composition, structural engineering, external stimuli).

Main Results:

  • Bimetallic nanozymes demonstrate diverse enzyme-like activities.
  • Activity modulation is achievable through compositional and structural modifications.
  • Significant potential demonstrated in tumor therapy, biosensing, environmental remediation, and food safety.

Conclusions:

  • Bimetallic nanozymes represent a promising class of artificial enzymes with broad applicability.
  • Further research is needed for rational design and translation into real-world applications.
  • Interdisciplinary approaches are crucial for advancing their potential.