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Oral Immunotherapy Induces Shift in lncRNA Expression Modulating Allergen-Specific Immune Responses.

Olivia Liong1, Kati Palosuo2, Victoria Hinkkanen1

  • 1Human Microbiome (HUMI) Research Program, Medical Faculty, University of Helsinki, Helsinki, Finland.

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|November 29, 2025
PubMed
Summary
This summary is machine-generated.

Oral immunotherapy (OIT) for egg allergy impacts long non-coding RNA (lncRNA) expression. Specific lncRNAs correlate with immune pathways, suggesting a role in desensitization and potential therapeutic targets.

Keywords:
desensitizationhen's egg allergylncRNAnetwork analysesoral immunotherapy

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Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Egg oral immunotherapy (OIT) successfully alleviates dietary restrictions in allergic children.
  • OIT is associated with reduced inflammation and altered gene expression in peripheral blood mononuclear cells (PBMCs).

Purpose of the Study:

  • To investigate the role of long non-coding RNAs (lncRNAs) in the immune response during egg OIT.
  • To identify lncRNAs that regulate allergen-specific immune responses following OIT.

Main Methods:

  • Analysis of PBMC transcriptome data from children undergoing OIT.
  • Co-expression gene module identification and pathway enrichment analyses.
  • In vitro stimulation of PBMC and THP1 cells to assess lncRNA function.

Main Results:

  • Seventeen lncRNAs positively correlated with IL-13, IL-4, and IL-10 signaling pathways.
  • These lncRNAs negatively correlated with pathways involved in neutrophil degranulation and pyroptosis.
  • The lncRNA LOC644727 expression correlated with CXCL8 in stimulated immune cells.

Conclusions:

  • lncRNAs are involved in regulating gene expression during OIT for egg allergy.
  • LOC644727 shows potential as a biomarker for inflammatory responses.
  • Targeting lncRNAs may offer new therapeutic strategies for OIT desensitization protocols.