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Oral Immunotherapy Induces Shift in lncRNA Expression Modulating Allergen-Specific Immune Responses
Olivia Liong1, Kati Palosuo2, Victoria Hinkkanen1
1Human Microbiome (HUMI) Research Program, Medical Faculty, University of Helsinki, Helsinki, Finland.
Allergy
|November 29, 2025
Summary
Oral immunotherapy (OIT) for egg allergy impacts long non-coding RNA (lncRNA) expression. Specific lncRNAs correlate with immune pathways, suggesting a role in desensitization and potential therapeutic targets.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- Egg oral immunotherapy (OIT) successfully alleviates dietary restrictions in allergic children.
- OIT is associated with reduced inflammation and altered gene expression in peripheral blood mononuclear cells (PBMCs).
Purpose of the Study:
- To investigate the role of long non-coding RNAs (lncRNAs) in the immune response during egg OIT.
- To identify lncRNAs that regulate allergen-specific immune responses following OIT.
Main Methods:
- Analysis of PBMC transcriptome data from children undergoing OIT.
- Co-expression gene module identification and pathway enrichment analyses.
- In vitro stimulation of PBMC and THP1 cells to assess lncRNA function.
Main Results:
- Seventeen lncRNAs positively correlated with IL-13, IL-4, and IL-10 signaling pathways.
- These lncRNAs negatively correlated with pathways involved in neutrophil degranulation and pyroptosis.
- The lncRNA LOC644727 expression correlated with CXCL8 in stimulated immune cells.
Conclusions:
- lncRNAs are involved in regulating gene expression during OIT for egg allergy.
- LOC644727 shows potential as a biomarker for inflammatory responses.
- Targeting lncRNAs may offer new therapeutic strategies for OIT desensitization protocols.
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