Comparison of the Effects of Hyoscine-N-Butylbromide and Ondansetron on Postoperative Nausea-Vomiting after...

Recent studies have demonstrated that hyoscine-n-butylbromide has an antiemetic effect. We aimed to compare the effects of hyoscine-n-butylbromide and ondansetron on postoperative nausea-vomiting (PONV) and pain after laparoscopic cholecystectomy.

In this randomized study, a total of 134 patients between 18 and 65 years, who underwent laparoscopic cholecystectomy, were divided into two groups, and their demographic data were recorded. After routine monitoring, induction was performed with propofol, fentanyl, and rocuronium, then sevoflurane, and remifentanil were used for maintenance. After gallbladder removal, IV infusion of 1000 mg paracetamol and 1.5 mg/kg tramadol was administered to the patients. Simultaneously, 20 mg hyoscine-n-butylbromide (HBB) in 100 ml saline was administered in Group-HBB, and 4 mg ondansetron infusion in 100 ml saline was administered in Group-O. The patients were followed up in terms of nausea and vomiting, and pain at the postoperative 15th and 30th minutes and at the 3rd, 6th, 12th, and 24th h.

Total PONV rate was found to be 38%. In the 24-h follow-up of the patients, PONV was observed at least once in 26 (39.4%) patients in Group-HBB, and in 25 (36.7%) patients in Group-O, and there was no difference between the two groups. Scores of PONV, antiemetic use rates, VAS scores, and analgesic use rates were similar during the 24-h follow-up.

The effects of hyoscine-n-butylbromide and ondansetron on PONV and pain are similar in laparoscopic cholecystectomy. In laparoscopic cholecystectomies, hyoscine-n-butylbromide is a good alternative for PONV prophylaxis in eligible patients.