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Updated: May 5, 2026

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Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
Published on: July 28, 2016
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Eosinophil Peroxidase as a Dynamic Indicator of Treatment Response in Eosinophilic Chronic Rhinosinusitis
Jacquelyn K Callander1, Annabelle R Charbit2, Camryn Marshall3
1Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, USA.
International Forum of Allergy & Rhinology
|November 29, 2025
Abstract
Key Points:
Eosinophil peroxidase (EPX) correlates with local type 2 inflammation and may serve as a noninvasive biomarker of eosinophilic chronic rhinosinusitis. EPX declines after surgery and dupilumab, highlighting its potential to track treatment response. High baseline EPX predicts patients likely to achieve a clinically meaningful Sinonasal Outcome Test-22 change.

