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SEOM-GEICAM-SOLTI clinical guidelines for early-stage breast cancer (UPDATE 2025)

Francisco Ayala de la Peña1, Silvia Antolín Novoa2, Joaquín Gavilá Gregori3

  • 1Department of Medical Oncology, Hospital General Universitario Gregorio Marañón, Hospital Oncológico y de Terapias Avanzadas, Calle Maiquez 7, 28007, Madrid, Spain. frayala@ucm.es.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|November 29, 2025
PubMed

Insights

This guideline updates early-stage breast cancer treatment strategies in Spain, incorporating new diagnostic tools and therapies like immunotherapy. It aims to improve patient outcomes while managing treatment toxicity effectively.

Area of Science:

  • Oncology
  • Clinical Practice Guidelines

Background:

  • Breast cancer is the leading cause of cancer among women in Spain, with a rising incidence.
  • Screening programs detect most cases at early, curable stages.
  • Advances in diagnostics and therapies are improving the efficacy and safety of breast cancer treatment.

Purpose of the Study:

  • To provide an updated clinical practice guideline for early-stage breast cancer management.
  • To integrate recent advancements in diagnostic tools and therapeutic strategies.
  • To offer expert consensus for optimal patient care in Spain.

Main Methods:

  • Systematic review of relevant scientific studies.
  • Consensus development among experts from GEICAM, SOLTI, and SEOM.
  • Focus on early-stage breast cancer (updated for 2025).

Main Results:

  • Identification of improved locoregional and systemic therapies.
  • Evaluation of novel strategies including immunotherapy, targeted drugs, and antibody-drug conjugates.
  • Assessment of enhanced toxicity-benefit balance in treatment.

Conclusions:

  • The guideline incorporates new diagnostic and therapeutic advancements for early-stage breast cancer.
  • It emphasizes optimizing treatment to improve outcomes and minimize toxicity.
  • It serves as a crucial resource for oncologists in Spain.
Keywords:
AdjuvantEarly breast cancerFollow-upNeoadjuvant

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