Preterm birth differentially impacts structural and functional connectivity of cortical gyri and sulci
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Preterm birth alters brain connectivity, reducing connections between cortical gyri and sulci. These changes impact brain function and are linked to prematurity, offering new insights into its effects.
Area Of Science
- Neuroscience
- Developmental Biology
- Medical Imaging
Background
- Preterm birth disrupts fetal brain development, particularly cortical gyrification.
- Cortical gyri and sulci exhibit distinct structural and functional roles in brain processing.
Purpose Of The Study
- To investigate the impact of preterm birth on the structural and functional patterns of gyral and sulcal regions.
- To understand how altered gyrification affects brain connectivity and function in preterm neonates.
Main Methods
- Utilized the Developing Human Connectome Project (dHCP) dataset (207 neonates).
- Parcellated brain regions into gyri and sulci using vertex curvature.
- Assessed structural connectivity with diffusion MRI (dMRI) and functional connectivity with fMRI BOLD signals.
Main Results
- Preterm birth was associated with reduced structural connectivity between gyri.
- A lower ratio of intra-gyri/gyri-sulci connections correlated with gestational age and birth weight.
- Network-based statistics revealed hypo-connections, particularly between gyri and sulci.
Conclusions
- Preterm birth differentially affects gyral and sulcal regions, potentially disrupting their specialized functions.
- Findings provide novel insights into the neurodevelopmental consequences of prematurity on brain organization and function.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...