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Characteristics of sleep disturbance in Moyamoya disease

Mudassar Ahmad1, James P Klaas2, Giuseppe Lanzino3

  • 1Center for Sleep Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Internal Medicine, Mayo Clinic, Rochester, MN, 55905, USA.

Sleep Medicine
|November 29, 2025
PubMed
Abstract

Insights

Poor sleep quality is prevalent in Moyamoya disease (MMD) patients, often indicating undiagnosed sleep disorders. Headaches and strokes were linked to worse sleep disturbances in MMD patients.

Area of Science:

  • Neurology
  • Sleep Medicine

Background:

  • Moyamoya disease (MMD) involves intracranial arterial steno-occlusion.
  • Common MMD symptoms include stroke, seizures, and headaches.
  • Sleep disturbance is linked to these symptoms in the general population, but unstudied in MMD.

Purpose of the Study:

  • To characterize self-reported sleep quality in adult Moyamoya disease patients.

Main Methods:

  • Cross-sectional retrospective analysis of 24 adult MMD patients.
  • Utilized the Pittsburgh Sleep Quality Index (PSQI) for sleep quality assessment.
  • Reviewed patient charts for documented sleep disorder diagnoses.

Main Results:

  • 62.5% of MMD patients reported poor sleep quality (PSQI > 5).
  • Only 5 patients had a diagnosed sleep disorder.
  • Higher PSQI scores were observed in patients with headaches (p < 0.001).

Conclusions:

  • Poor sleep quality is common in MMD patients, suggesting potential undiagnosed sleep disorders.
  • Sleep disturbances are more pronounced in MMD patients experiencing headaches and strokes.
  • Further research is needed on the impact of sleep disturbances and their treatment on MMD patient quality of life.
Keywords:
HeadacheMoyamoyaPSQISleep qualityStroke

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