Related Experiment Video
Updated: Jan 9, 2026
12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
19.3K
Understanding Glycemia in the Post Discharge Period Through Blinded Continuous Glucose Monitoring
Rahul Patel1, Mollie Y O'Connor2, Amy Sabean1
1Diabetes Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Summary
Post-hospital discharge glucose control for diabetes patients is often suboptimal. Continuous glucose monitoring (CGM) can identify hypoglycemia and inpatient glucose levels may predict post-discharge glycemic control.
Area of Science:
- Endocrinology
- Diabetes Management
- Medical Devices
Background:
- Hospital discharge is a critical transition for diabetes patients.
- Glycemic control in the immediate post-discharge period is not well understood.
Purpose of the Study:
- To assess glycemia in adults with diabetes during the immediate post-hospital discharge period.
- To evaluate the utility of continuous glucose monitoring (CGM) in this setting.
Main Methods:
- Observational study using blinded Dexcom G6 Pro CGM in 24 adults.
- CGM worn during hospitalization and for up to 10 days post-discharge.
- Analysis of time in range (TIR), time above range, and time below range; incidence of hypoglycemia.
Main Results:
- Mean post-discharge TIR was 43.9%, with 41.7% achieving ≥50% TIR.
- Glycemia remained similar between inpatient and post-discharge periods.
- Inpatient glycemia predicted post-discharge glycemic targets; 25% experienced post-discharge hypoglycemia.
Conclusions:
- Post-discharge glycemia in diabetes patients is suboptimal.
- Inpatient glucose control may predict post-discharge outcomes.
- CGM shows potential for detecting post-discharge hypoglycemia.
More Related Videos
Related Concept Videos
01:15Hypoglycemia and Glucagon
778
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
778
01:02Glucose Homeostasis: Regulation of Blood Glucose
3.7K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
3.7K
01:22Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
01:15Diabetes: Management and Pharmacotherapy
848
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
848
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
01:16Hormones Regulating Blood Glucose
6.3K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
6.3K