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Correlation analysis of the inflammatory composite index in patients with coronary heart disease

Fengqi Liu1, Shutong Ding2, Aohui Chen1

  • 1Department of Cardiology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China; Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China.

The American Journal of the Medical Sciences
|November 29, 2025
PubMed

Insights

The inflammatory composite index (ICI) is linked to acute coronary syndrome (ACS) in heart disease patients. Combining ICI with total cholesterol improves diagnostic accuracy for ACS.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Identifying reliable biomarkers for acute coronary syndrome (ACS) is crucial for timely intervention.
  • The inflammatory composite index (ICI), derived from neutrophil count and free triiodothyronine, warrants investigation for its role in CHD.

Purpose of the Study:

  • To explore the association between the inflammatory composite index (ICI) and coronary heart disease (CHD).
  • To evaluate the diagnostic efficacy of ICI, alone and in combination with total cholesterol (TC), for acute coronary syndrome (ACS).

Main Methods:

  • A retrospective study involving 1481 CHD patients (Jiangnan University) and 810 CHD patients (Soochow University).
  • Patients were categorized into acute coronary syndrome (ACS) and chronic coronary syndromes (CCS) groups.
  • Binary logistic regression and ROC curve analysis were employed to assess risk factors and diagnostic value.

Main Results:

  • The ICI was significantly higher in the ACS group compared to the CCS group (p < 0.001).
  • ICI was identified as an independent risk factor for ACS in CHD patients (OR=1.099, p < 0.001).
  • Combined ICI and TC demonstrated superior diagnostic accuracy (AUC=0.740) compared to either marker alone (AUC=0.693 for ICI, AUC=0.676 for TC).

Conclusions:

  • The inflammatory composite index (ICI) is significantly correlated with the occurrence of ACS in patients with coronary heart disease.
  • ICI holds potential as a diagnostic biomarker for ACS.
  • Combining ICI with total cholesterol enhances diagnostic performance for ACS in CHD patients.
Abstract

Keywords:
Acute coronary syndromeChronic coronary syndromeInflammatory complex indexNon-thyroid disease syndrome

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