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Mapping Dysfunctional Protein-Protein Interactions in Disease
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Folliculin-interacting protein 1: From molecular structure to disease and therapeutic targets

Youxin Liang1, Guixia Zhang1, Xintian Chen1

  • 1Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.

Biochemical Pharmacology
|November 29, 2025
PubMed

Insights

Folliculin-interacting protein 1 (FNIP1) is crucial for metabolic regulation and influences various diseases. This review highlights FNIP1's structure and potential as a therapeutic target for conditions like diabetes and cancer.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Metabolic Research

Background:

  • Folliculin-interacting protein 1 (FNIP1) plays a vital role in metabolic regulation and cellular processes.
  • Its involvement in energy homeostasis, cell fate, and disease pathogenesis is increasingly recognized.
  • The therapeutic potential of FNIP1 remains underexplored.

Purpose of the Study:

  • To review recent advancements in FNIP1 research.
  • To explore the structural basis of FNIP1's function and its role in disease.
  • To evaluate FNIP1 as a potential drug-therapy target.

Main Methods:

  • Literature review of recent studies on FNIP1.
  • Analysis of structural determinants influencing FNIP1 function.
  • Examination of metabolic pathways and pathological conditions linked to FNIP1 dysregulation.

Main Results:

  • FNIP1 exhibits functional plasticity influenced by its structure.
  • FNIP1 modulates key metabolic pathways through crosstalk with other regulators.
  • Dysregulation of FNIP1 is associated with neurodegenerative diseases, type 2 diabetes, and tumors.

Conclusions:

  • FNIP1's structure provides a basis for its therapeutic targeting.
  • Developing FNIP1-related drugs holds promise for treating metabolic and other diseases.
  • Establishing functional correlations can guide precision therapeutic strategies targeting FNIP1.
Keywords:
DiseaseDrug targetEnergy metabolismFolliculin-interacting protein 1Hsp90 co-chaperoneImmune cell developmentReductive stress

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