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Carbon-ion Radiotherapy for Hepatocellular Cancer Arising in Transplanted Liver Tissue.

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  • 1Department of Radiology, Osaka Heavy Ion Therapy Center, Osaka, Japan; hayashi@radonc.med.osaka-u.ac.jp.

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Summary

Carbon-ion radiotherapy (CIRT) offers a safe treatment for hepatocellular carcinoma (HCC) in transplanted livers. This case study shows no HCC recurrence after CIRT, suggesting its potential efficacy in managing this rare complication.

Keywords:
Carbon-ion radiotherapyHCCdefinitive radiotherapyhepatocellular carcinomatransplanted liver

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Area of Science:

  • Oncology
  • Hepatology
  • Radiotherapy

Background:

  • Hepatocellular carcinoma (HCC) in transplanted liver tissue is rare.
  • Limited data exists on radiotherapy's effects on HCC in transplanted livers.
  • Safety and efficacy of radiotherapy for this condition are unclear.

Purpose of the Study:

  • To report a case of carbon-ion radiotherapy (CIRT) for HCC in a transplanted liver.
  • To evaluate the safety and efficacy of CIRT for HCC in a liver transplant recipient.

Main Methods:

  • A 51-year-old male with a history of liver transplantation received CIRT for recurrent HCC.
  • The patient underwent CIRT at 60 Gy (RBE) in four fractions.
  • Follow-up included imaging and liver function tests.

Main Results:

  • No acute adverse events were observed during CIRT.
  • Transient grade 2 increase in gamma-glutamyl transpeptidase normalized naturally.
  • No HCC recurrence was observed for over 4 years and 7 months post-treatment.

Conclusions:

  • Carbon-ion radiotherapy (CIRT) appears to be a safe treatment option for HCC in transplanted liver tissue.
  • CIRT demonstrated potential efficacy in preventing HCC recurrence in this case.