Contemporary, non-invasive imaging diagnosis of chronic coronary artery disease

Pieter van der Bijl1, Martha Gulati2, Antti Saraste3

  • 1Department of Cardiology, Leiden University Medical Centre, Leiden, Netherlands; SA Endovascular, Netcare Kuils River Hospital, Cape Town, South Africa.

Lancet (London, England)
|November 29, 2025
PubMed

Insights

This review covers diagnosing chronic coronary artery disease, focusing on cardiac imaging techniques. It compares anatomical and functional tests and explores artificial intelligence applications for better patient outcomes.

Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Coronary artery disease (CAD) is a major global health burden, leading to significant morbidity and mortality.
  • While CAD can manifest acutely, it frequently presents as a chronic, stable condition.

Purpose of the Study:

  • To provide a comprehensive overview of diagnosing chronic coronary artery disease.
  • To focus on the role and comparison of various cardiac imaging modalities.

Main Methods:

  • Review of current literature on cardiac imaging for CAD diagnosis.
  • Discussion of CT coronary angiography, stress echocardiogram, SPECT, PET, and cardiac MRI.
  • Comparative analysis of anatomical versus functional imaging tests.

Main Results:

  • Cardiac imaging plays a crucial role in diagnosing chronic coronary artery disease.
  • CT coronary angiography offers anatomical detail, while stress echocardiography provides functional information.
  • Artificial intelligence shows potential for enhancing diagnostic accuracy.

Conclusions:

  • Accurate diagnosis of chronic coronary artery disease relies heavily on appropriate cardiac imaging selection.
  • A combination of anatomical and functional imaging may be optimal for patient stratification.
  • Future directions include integrating AI into cardiac imaging workflows for improved CAD management.

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