Copper-Catalyzed Trifluoromethylalkynylation via Radical-Mediated Multicomponent Process
Mai Zhang1, Jia Ni1, Mengtao Ma1
1Department of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing, China.
Chemistry, an Asian Journal
|November 29, 2025
Summary
This study introduces a copper-catalyzed reaction for synthesizing complex molecules. The efficient method uses Togni
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- Multicomponent reactions (MCRs) are essential for efficient molecular assembly.
- Developing new MCRs expands synthetic capabilities for complex molecule construction.
Purpose of the Study:
- To develop an efficient copper-catalyzed multicomponent reaction.
- To synthesize β-trifluoromethyl propynes with high regioselectivity.
Main Methods:
- Utilized Togni's reagent II, alkenes, and alkynes in a copper-catalyzed process.
- Employed mild reaction conditions to promote chemoselectivity and regioselectivity.
Main Results:
- Achieved efficient synthesis of β-trifluoromethyl propynes.
- Demonstrated high regioselectivity in the trifluoromethylalkynylation of alkenes.
- Showcased broad substrate scope and excellent functional group tolerance.
Conclusions:
- The developed method offers a practical and efficient route to valuable trifluoromethylated compounds.
- This copper-catalyzed radical process is a versatile tool for organic synthesis.
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