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Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
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Renal nerve stimulation modulates renal blood flow in a frequency-dependent manner

Dzifa Kwaku1, Dusty Van Helden2, Joan Dao1

  • 1Department of Biomedical Engineering, University of Minnesota, Minneapolis, USA.

Bioelectronic Medicine
|November 29, 2025
PubMed
Summary

Kilohertz-frequency electrical stimulation reversibly inhibits renal nerve activity, offering a potential alternative to renal denervation for hypertension. This study explored its effects on renal blood flow in swine, finding frequency-dependent responses and lasting changes in nerve sensitivity.

Keywords:
Blood pressureHypertensionKilohertz-frequency stimulationPeripheral nerve stimulationRenal blood flowRenal nerve

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