Frailty and transitions across cardiometabolic disease states: evidence from multistate models in a 16-year Chinese cohort
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View abstract on PubMed
Summary
This summary is machine-generated.Frailty accelerates the progression of cardiometabolic diseases (CMD), including transitions to multimorbidity and death. Routine frailty assessment is crucial for preventing CMD.
Area Of Science
- Gerontology
- Cardiology
- Metabolic Medicine
Background
- Frailty is a common geriatric syndrome.
- Its impact on cardiometabolic disease (CMD) progression is not fully understood.
Purpose Of The Study
- To investigate if frailty predicts transitions in cardiometabolic disease (CMD).
- To analyze the dynamic role of frailty in cardiometabolic multimorbidity (CMM) and mortality.
Main Methods
- Utilized data from 22,754 participants aged 50+ in the Guangzhou Biobank Cohort Study.
- Assessed frailty using a 35-item frailty index (FI).
- Employed Cox and multistate models to analyze associations with CMD development, CMM, and mortality.
Main Results
- Frailty significantly accelerated transitions from health to first CMD (FCMD), FCMD to CMM, and CMM to death.
- Higher FI scores correlated with increased risk of CMD progression and mortality.
- Multistate models revealed frailty's dynamic role in multimorbidity progression.
Conclusions
- Frailty is an independent predictor of cardiometabolic disease progression and mortality.
- Routine frailty assessment should be integrated into cardiometabolic prevention strategies.
- Understanding frailty's dynamic role is key to managing multimorbidity.
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