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Related Experiment Video

Updated: Jan 9, 2026

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Biotic-Abiotic Interface Engineering for Peripheral Nerve Modulation and Repair.

Janghwan Jekal1, Jin Tae Park2, Eunmi Kim3

  • 1Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 42988, Republic of Korea.

Small Methods
|November 30, 2025
PubMed
Summary
This summary is machine-generated.

Peripheral nerve interfaces are advancing neuroengineering for therapeutic and prosthetic uses. These systems offer interactive, personalized platforms for neural repair and modulation, moving beyond passive interventions.

Keywords:
biotic‐abiotic interfaceimplantable deviceneuromodulationperipheral nerve interfacewearable device

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Area of Science:

  • Neuroengineering
  • Biomaterials Science
  • Neural Interfaces

Background:

  • The peripheral nervous system (PNS) presents a promising target for neuroengineering due to its accessibility and regenerative potential.
  • Peripheral nerve interfaces (PNIs) are crucial for therapeutic and prosthetic applications, aiming to record, stimulate, or repair neural pathways.
  • Current advancements focus on integrating surgical and functional aspects with adaptive, closed-loop control systems.

Purpose of the Study:

  • To review recent progress in biotic-abiotic interface engineering for peripheral nerve applications.
  • To highlight the evolution of PNIs towards interactive and personalized platforms.
  • To discuss challenges and future directions in the field.

Main Methods:

  • Review of recent literature on peripheral nerve interface technologies.
  • Analysis of wearable and implantable approaches in neuroengineering.
  • Synthesis of current trends in adaptive, closed-loop neural control systems.

Main Results:

  • PNIs are transitioning from passive to interactive, responsive, and personalized systems.
  • Biotic-abiotic interface engineering is key to developing advanced PNIs.
  • Wearable and implantable technologies are expanding the scope of PNI applications.

Conclusions:

  • Peripheral nerve interfaces represent a significant advancement in neural repair and modulation.
  • The convergence of technologies enables sophisticated, adaptive control for neural applications.
  • Continued innovation in interface engineering is essential for future PNI development.