Related Experiment Video
Updated: Jan 9, 2026

Bioluminescent Bacterial Imaging In Vivo
Published on: November 4, 2012
Engineered Bacterial Therapeutics: Controlled Release Approaches in Oncology
Zetao Yu1, Ruijie Nie1, Wenna Li2
1Senior Department of Hepato-Pancreato-Biliary Surgery, The First Medical Center of the Chinese People's Liberation Army (PLA) General Hospital, Medical School of Chinese PLA, 28 Fuxing Road, Beijing, 100853, China.
Abstract:
Engineered bacterial therapeutics are gaining attention in tumor therapy, showing significant clinical potential. However, their clinical translation requires stricter regulation of biosafety and targeting specificity. Controlled release systems offer a key strategy to optimize engineered bacteria through precise spatiotemporal gene expression and motility modulation. This review systematically evaluates two core controlled-release platforms in tumor treatment-tumor microenvironment-responsive systems and intelligent controllable systems-summarizes representative therapeutic paradigms and critically analyzes the merits and limitations of each. Therefore, this review aims to provide a theoretical foundation for refining controlled-release strategies in engineered bacteria-mediated antitumor therapy.
Related Concept Videos
Microorganisms in Medicine and Therapeutics
Targeted Cancer Therapies
There are several types of targeted therapies against...
Biological Methods for Microbial Control
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

