Histology Atlas of the Developing Mouse Digestive System With Emphasis From Prenatal Day 7.5 Through Early Postnatal Development
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View abstract on PubMed
Summary
This summary is machine-generated.This study presents a microscopic atlas detailing mouse digestive system development from embryonic day 7.5 to postnatal day 21. It provides crucial insights into normal anatomy and aids in identifying developmental abnormalities.
Area Of Science
- Developmental Biology
- Anatomy
- Genetics
Background
- Digestive system development is complex, involving precise molecular signaling from the primitive gut tube.
- Abnormal development leads to human birth defects affecting digestion and nutrient uptake.
- Mouse models are vital for understanding mammalian digestive system formation.
Purpose Of The Study
- To create a comprehensive microscopic atlas of digestive tract development in wild-type mice.
- To document key developmental milestones from embryonic to weaning stages.
- To provide a resource for identifying abnormal phenotypes and toxic effects.
Main Methods
- Utilized high-resolution, well-annotated color images.
- Tracked digestive system anatomy from embryonic day 7.5 to postnatal day 21.
- Included comparisons with human developmental features.
Main Results
- Detailed key developmental milestones of the upper and lower digestive tracts.
- Illustrated the evolution of digestive system anatomy.
- Highlighted the formation of adult-like features at weaning.
Conclusions
- This atlas serves as an essential resource for studying normal and abnormal digestive system development in mice.
- Understanding normal development is critical for diagnosing birth defects and toxicological effects.
- The atlas facilitates comparative analysis with human digestive development.
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