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Histology of the Gastrointestinal (GI) Tract01:20

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Histopathological Profile of Gastrointestinal Cancer.

Baishali Bhattacharya1, Reechashree Dhungana2, Naveen Gautam2

  • 1Samyak Pathology Lab, Mid-Baneshwor, Kathmandu, Nepal.

Journal of Nepal Health Research Council
|November 30, 2025
PubMed
Summary
This summary is machine-generated.

Gastric cancer was most common among gastrointestinal (GI) epithelial cancers in Nepal, with a male predominance observed across all types. Rising colorectal cancer suggests lifestyle factors may be involved.

Keywords:
Colorectal neoplasms; epidemiology; gastrointestinal neoplasms; Nepal; stomach neoplasms.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Gastrointestinal (GI) epithelial cancers are a significant global health burden, contributing to numerous cancer-related deaths.
  • Understanding the specific epidemiological, symptomatic, and histopathological patterns of these cancers is crucial for targeted public health interventions.

Purpose of the Study:

  • To analyze the epidemiology, symptomatology, and histopathology of gastrointestinal epithelial malignancies.
  • To provide insights into the patterns of GI cancers in Kathmandu, Nepal.

Main Methods:

  • An observational study analyzed data from biopsy specimens, pathology reports, and clinical/endoscopic information.
  • Data from March 2017 to December 2018 at Samyak Pathology Lab (SPL), Kathmandu, were included, excluding nonepithelial tumors.
  • Microsoft Excel 365 was used for data analysis.

Main Results:

  • Gastric cancer was the most frequent (39.9%), followed by colorectal (33.5%), duodenal/ampullary (14.3%), and esophageal (12.3%) cancers.
  • Male predominance was noted across all cancer types, with varying mean ages and common symptoms (e.g., abdominal pain for gastric, dysphagia for esophageal, jaundice for duodenal, rectal bleeding for colorectal).
  • Gastric cancer showed a mean age of 59.7 years (M:F ratio 2.4), esophageal 65.8 years (M:F 2.6), duodenal 57.2 years (M:F 1.2), and colorectal 54 years (M:F 1.6).

Conclusions:

  • Gastric cancer was the most prevalent GI epithelial malignancy in this Nepalese cohort.
  • A male predominance was observed, and an increase in colorectal carcinoma suggests potential links to lifestyle changes.