Clinical Response to Amoxicillin among Children with Acute Suppurative Otitis Media
Deepa Joshi1, Ajit Nepal2, Namita Shrestha2
1Department of ENT and HNS, Bir hospital, NAMS, Kathmandu.
Insights
High-dose oral amoxicillin effectively treats Acute Suppurative Otitis Media (ASOM) in children. This study found most children responded well to amoxicillin, a common antibiotic for this childhood infection.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Acute Suppurative Otitis Media (ASOM) is a frequent childhood illness.
- Amoxicillin is a primary antibiotic choice for ASOM in various healthcare settings.
Purpose of the Study:
- To evaluate the efficacy of high-dose oral amoxicillin in treating pediatric ASOM.
- To assess clinical responsiveness to amoxicillin therapy in children with ASOM.
Main Methods:
- A prospective, hospital-based observational cross-sectional study.
- Included ASOM patients under 14 years with symptoms < 6 weeks.
- Collected ear discharge for microbiological analysis and treated with amoxicillin (80mg/kg/day).
Main Results:
- Out of 32 cases, 19 showed microbial growth; 9 were sensitive and 10 resistant to amoxicillin.
- Coagulase-negative Staphylococcus was the most frequent pathogen.
- 31 out of 32 patients responded to high-dose amoxicillin after one week.
Conclusions:
- High-dose oral amoxicillin demonstrates effectiveness in treating pediatric ASOM.
- Amoxicillin remains a viable treatment option for childhood ASOM.
Background:
Acute Suppurative Otitis Media(ASOM) is a very common disease of childhood caused by various bacteria and viruses. Amoxicillin is used as first line antibiotics in the community setting as well as hospital setting.
Methods:
This is a hospital based prospective observational cross-sectional study. All cases of ASOM of patients under 14 years presenting to the Patan Hospital with duration of less than 6weeks were included in the study. Ear discharge was collected using sterile cotton swab using aseptic precautions and sent to the Department of Microbiology for further processing. The children were treated with amoxicillin (80mg/kg/day) with maximum dose not exceeding 3g/day and follow up was done after 1 week of antibiotic therapy for clinical responsiveness.
Results:
Out of 32 cases, 13 cases showed no growth of organism in the culture sensitivity reports. Among remaining 19 cases, 9 were sensitive and 10 were resistant to amoxicillin. Coagulase negative Staphylococcus (7) was the most common organism grown in the laboratory followed by Staphylococcus aureus (4) and Klebsiella pneumoniae (4). Chloramphenicol, linezolid, clindamycin and trimethoprim-sulphamethoxazole were the most common antibiotics sensitive to the organisms grown besides amoxicillin. Out of total 32 patients, 31 were responsive to high dose amoxicillin at the end of 1 week.
Conclusions:
Oral amoxicillin in high doses is effective in the treatment of ASOM in children.
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