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Iron Profile Variability in Hemodialysis Chronic Kidney Disease Patients

Collince Odiwuor Ogolla1, Lucy W Karani1, Stanslaus Musyoki2

  • 1Department of Applied Health Science, School of Health Science, Kisii University, Kisii, Kenya.

Journal of Clinical Laboratory Analysis
|November 30, 2025
PubMed

Insights

Dialysis adherence is crucial for managing iron deficiency anemia in chronic kidney disease (CKD) patients. Patients who adhere to dialysis show significantly better iron profiles and lower rates of anemia.

Area of Science:

  • Nephrology
  • Hematology
  • Internal Medicine

Background:

  • Chronic kidney disease (CKD) is a major global health concern.
  • Iron deficiency (ID) anemia is a common complication in CKD patients, particularly those on dialysis.

Purpose of the Study:

  • To compare iron profiles between dialysis-adherent and non-adherent CKD patients.
  • To analyze the relationship between dialysis adherence and iron status.

Main Methods:

  • A cross-sectional study included 120 hemodialysis patients.
  • Patients were categorized based on dialysis adherence.
  • Iron profile parameters (serum ferritin, TSAT, hemoglobin, serum iron) were assessed.
  • Multivariate regression analysis adjusted for confounders.

Main Results:

  • Adherent patients had significantly higher serum ferritin, TSAT, and hemoglobin levels.
  • Non-adherence was linked to a higher prevalence of iron deficiency anemia (63% vs. 40%).
  • Dialysis adherence independently predicted better iron status.

Conclusions:

  • Adherence to dialysis is a strong predictor of improved iron profile in hemodialysis patients.
  • Strategies to enhance adherence and optimize iron metabolism in CKD patients are recommended.
Abstract

Keywords:
chronic kidney diseasedialysis adherenceiron deficiency anemiairon profileserum ferritintransferrin saturation

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