Related Experiment Video
Updated: Jan 6, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Building a Beta-Lactam Model-Informed Precision Dosing Service in a Quaternary Care Children's Hospital.
Sonya Tang Girdwood1,2,3, Ronaldo Morales Junior1, Erin Schuler3,4
1Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Precision dosing of cefepime antibiotics was achieved through a new pharmacokinetic (PK) consult service using model-informed precision dosing (MIPD). This service provides personalized antibiotic recommendations for pediatric patients.
Area of Science:
- Pharmacology
- Pediatric Medicine
- Antibiotic Stewardship
Background:
- Growing interest in precision dosing for beta-lactam antibiotics.
- Existing infrastructure for pharmacokinetic (PK) consult services for other drugs.
Purpose of the Study:
- Describe the development of a novel beta-lactam PK consult service.
- Address challenges in establishing a specialized antibiotic dosing service.
- Provide a workflow and infrastructure guide for similar services.
Main Methods:
- Utilized a model-informed precision dosing (MIPD) approach for cefepime.
- Leveraged existing PK consult service infrastructure.
- Detailed the workflow and addressed inter-service differences.
Main Results:
- Successfully launched a new PK consult service for beta-lactam antibiotics.
- Identified and addressed challenges related to evidence levels and service integration.
- Developed a replicable model for beta-lactam PK consult services.
Conclusions:
- Model-informed precision dosing (MIPD) is effective for cefepime in pediatric care.
- Early stakeholder engagement and phased drug implementation are crucial for service success.
- The described workflow can guide other institutions in establishing similar services.
More Related Videos
10:50Design and Use of a Low Cost, Automated Morbidostat for Adaptive Evolution of Bacteria Under Antibiotic Drug Selection
Published on: September 27, 2016
11:28A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
Published on: September 9, 2015
Related Concept Videos
Drug Dosing: Infants and Children
Pharmacokinetics in Pediatric Patients: Drug Excretion
Estimation of k and VD of Aminoglycosides
Dosage Regimens: Designs and Approaches
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses