Related Experiment Video

Updated: Jan 9, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

510

Management of prematurity-associated lung disease from infancy through to adulthood

Liesbeth Duijts1, Petra Um Bergström2, Sarah J Kotecha3

  • 1Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

The Lancet. Respiratory Medicine
|November 30, 2025
PubMed

Insights

Prematurity-associated lung disease (PLD) requires comprehensive management, including prevention, targeted treatments, and monitoring. Addressing both lung and non-lung issues is crucial for lifelong health in affected individuals.

Area of Science:

  • Pulmonology
  • Neonatology
  • Pediatric Respiratory Medicine

Background:

  • Preterm birth leads to long-term lung problems, including prematurity-associated lung disease (PLD).
  • PLD significantly impacts individuals throughout their lives, necessitating ongoing medical attention.

Purpose of the Study:

  • To summarize current evidence on the treatment and monitoring of PLD and its various phenotypes.
  • To highlight emerging preventive strategies and pharmacological interventions for PLD.
  • To emphasize the importance of managing extrapulmonary complications associated with PLD.

Main Methods:

  • Review of current evidence on PLD treatment and monitoring.
  • Discussion of preventive strategies like vaccination.
  • Exploration of pharmacological treatments and their phenotype-specific responses.
  • Consideration of extrapulmonary comorbidities and environmental factors.
  • Evaluation of monitoring tools and follow-up recommendations.
  • Identification of opportunities for drug repurposing and new therapy development.

Main Results:

  • Preventive strategies, such as maternal and infant vaccination, are key interventions.
  • Inhaled corticosteroids and bronchodilators show potential benefits in childhood PLD.
  • Management must encompass extrapulmonary conditions like cardiovascular issues and neurodevelopmental disabilities.
  • Structured follow-up from infancy to adulthood is recommended for comprehensive care.

Conclusions:

  • Effective management of prematurity-associated lung disease (PLD) requires a multifaceted approach.
  • Early identification, tailored treatments, and long-term monitoring are essential for improving outcomes.
  • Further research into phenotype-specific treatments and novel therapies is warranted for PLD patients.

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.7K
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

51.8K

Related Concept Videos

Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
3.1K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
3.4K
Chronic Obstructive Pulmonary Disease-V: Nursing Management01:30

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
5.0K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
705
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
731
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
447