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Related Concept Videos

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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. A Uk National Prospective Cohort Study Investigating Current Practices In Single-event Multilevel Surgery For Children With Bilateral Cerebral Palsy And Its Impact On Gait And Function: The Cpinboss Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. A Uk National Prospective Cohort Study Investigating Current Practices In Single-event Multilevel Surgery For Children With Bilateral Cerebral Palsy And Its Impact On Gait And Function: The Cpinboss Study.

Related Experiment Video

Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy
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A UK national prospective cohort study investigating current practices in single-event multilevel surgery for children with bilateral cerebral palsy and its impact on gait and function: the CPinBOSS study.

Tim Theologis1, Jacqueline Birks2, Julie Stebbins2

  • 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

The Bone & Joint Journal
|November 30, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

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Single-event multilevel surgery (SEMLS) shows effectiveness in improving gait and motor function in ambulant children with cerebral palsy (CP). This study highlights the need for standardized SEMLS practices across the UK for better patient outcomes.

Area of Science:

  • Orthopedics
  • Pediatric Surgery
  • Rehabilitation Medicine

Background:

  • Ambulant children with cerebral palsy (CP) often experience functional decline.
  • Single-event multilevel surgery (SEMLS) is a complex intervention aimed at improving mobility.

Purpose of the Study:

  • To determine the number of eligible children for SEMLS in the UK.
  • To investigate regional variations in SEMLS care.
  • To estimate the two-year outcomes of SEMLS in ambulant children with CP.

Main Methods:

  • Prospective, comprehensive cohort study of ambulant children with bilateral CP.
  • Inclusion criteria: 188 children meeting specific criteria.
  • Data collection: case mix, surgical procedures, and clinical outcomes (Gait Profile Score, Gait Outcomes Assessment List, Functional Mobility Scale).

Main Results:

  • 139 children underwent SEMLS, averaging 5.3 procedures per patient.
  • Significant improvement in Gait Profile Score and parental perception of motor function at two years post-SEMLS.
  • Complications reported in 18% of patients; non-surgical group showed gait decline.

Conclusions:

  • SEMLS demonstrates effectiveness in improving gait and motor function in ambulant children with CP.
  • Considerable variation in surgical practices exists across UK sites.
  • Standardization of clinical practice and further outcome studies are recommended.