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Updated: Jul 30, 2026
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
26.2K
Eight-year single- center experience with double-layer carotid stent.
Gianbattista Parlani1, Giacomo Isernia1, Lydia Romano1
1Unit of Vascular and Endovascular Surgery, S Maria Misericordia University Hospital, Perugia, Italy.
Journal of Vascular Surgery
|November 30, 2025
Summary
The CGuard stent with embolic protection system demonstrated safety and efficacy in carotid artery stenting (CAS). This micromesh device achieved high technical success and low rates of stroke and death during perioperative and mid-term follow-up.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Medical Device Technology
Background:
- Carotid artery stenosis (CAS) poses a significant risk of stroke.
- Carotid artery stenting (CAS) is an alternative to endarterectomy for CAS treatment.
- The CGuard micromesh stent with an embolic protection system aims to improve CAS outcomes.
Purpose of the Study:
- To evaluate the safety and efficacy of the CGuard stent during CAS.
- To assess perioperative and mid-term outcomes, including neurological events and device patency.
Main Methods:
- Prospective evaluation of 218 patients undergoing 226 CAS procedures with the CGuard stent.
- Primary endpoints included technical success, 30-day stroke/death, and ipsilateral stroke.
- Secondary endpoints included major adverse events and restenosis during follow-up.
Main Results:
- Technical success rate was 99.5%.
- 30-day major adverse event rate was 0.5% (1 transient ischemic attack, 1 minor stroke).
- Mid-term follow-up showed durable patency and low rates of stroke and restenosis.
Conclusions:
- The CGuard stent is effective and safe for CAS.
- Low perioperative and mid-term neurological event rates were observed.
- Further multicenter randomized studies are recommended to confirm findings.
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