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Related Concept Videos

Fungal Group Zygomycota01:29

Fungal Group Zygomycota

958
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
958

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Use of Image Cytometry for Quantification of Pathogenic Fungi in Association with Host Cells
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How Can Pathologists Contribute to Diagnosing Rare Fungal Infections?

Sota Sadamoto1,2, Masatomo Kimura3, Kazutoshi Shibuya4

  • 1Department of Surgical Pathology, Toho University School of Medicine.

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|November 30, 2025
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Histopathology is crucial for diagnosing rare fungal infections when other methods fail. Combining it with molecular techniques improves accuracy and guides effective antifungal treatment.

Keywords:
formalin-fixed paraffin-embedded tissuefungal infectionhistopathologyin situ hybridizationpolymerase chain reaction

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Area of Science:

  • Medical Mycology
  • Pathology
  • Infectious Diseases

Background:

  • Histopathological examination is vital for diagnosing fungal infections.
  • Culture and serological tests often face diagnostic challenges.
  • Identifying fungal species guides antifungal therapy selection.

Purpose of the Study:

  • To review the role of histopathology in diagnosing rare fungal infections.
  • To highlight the benefits of combining histopathology with molecular techniques.
  • To emphasize the pathologist's role in identifying invasive fungal infections.

Main Methods:

  • Review of current diagnostic approaches for fungal infections.
  • Discussion of limitations in morphological identification of fungi.
  • Integration of molecular techniques (PCR, sequencing) with histopathology.

Main Results:

  • Histopathology is essential for confirming fungal infections, especially rare ones.
  • Molecular techniques enhance diagnostic accuracy for difficult cases.
  • Combined histopathological and molecular approaches improve antifungal treatment precision.

Conclusions:

  • Histopathology is indispensable for diagnosing rare invasive fungal infections.
  • The combination of morphology and molecular data offers the most effective diagnostic strategy.
  • Accurate diagnosis by pathologists leads to improved patient outcomes through targeted antifungal therapy.