Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

450
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
450
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

467
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
467
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.8K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.8K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.4K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.4K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

708
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
708
Schizophrenia01:17

Schizophrenia

685
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
685

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mixed adenoneuroendocrine carcinoma of the gallbladder: a case report and literature review.

Frontiers in oncology·2026
Same author

Role of tyrosinase in ocular growth and myopia development in a guinea pig model.

Scientific reports·2026
Same author

Interfacial chemical compatibility-driven coumarin sensitization of two-dimensional rare-earth oxide nanoplatelets.

Nanoscale·2026
Same author

Retraction Note: Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer.

Nature communications·2026
Same author

Density-mediated freshwater plastisphere microbiomes preferentially degrade conventional rather than biodegradable microplastics.

The ISME journal·2026
Same author

Letrozole and Infertility Among Males With Spermatogenic Failure: A Randomized Clinical Trial.

JAMA network open·2026

Related Experiment Video

Updated: Jan 9, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.4K

Causal Relationship Between Hypertension and Schizophrenia.

ChaoBiao Xue1, Yifan Sun2, Weiyuan He3

  • 1Department of Psychological Medicine, Shantou Central Hospital.

International Heart Journal
|November 30, 2025
PubMed
Summary

This study found no causal link between hypertension and schizophrenia using genetic data. Bidirectional Mendelian randomization analysis confirmed that neither condition directly causes the other, offering clarity on their complex relationship.

Keywords:
Genome-wide association studies (GWAS)

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.4K
Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.2K

Related Experiment Videos

Last Updated: Jan 9, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.4K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.4K
Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.2K

Area of Science:

  • Genetics
  • Psychiatry
  • Cardiovascular Health

Background:

  • Hypertension is a major global health issue and risk factor for various diseases.
  • Schizophrenia is a chronic psychiatric disorder with significant individual and societal impact.
  • The relationship between hypertension and schizophrenia is complex and not fully understood.

Purpose of the Study:

  • To investigate the potential causal relationship between hypertension and schizophrenia.
  • To determine if hypertension causally influences schizophrenia risk.
  • To assess if schizophrenia causally influences hypertension risk.

Main Methods:

  • Utilized bidirectional Mendelian randomization (MR) analysis.
  • Employed genetic instruments derived from genome-wide association study (GWAS) datasets.
  • Applied the inverse-variance weighted (IVW) method with sensitivity analyses for robustness.

Main Results:

  • No significant causal association was found between genetically predicted hypertension and schizophrenia risk in discovery, validation, and meta-analysis groups.
  • Genetically predicted schizophrenia showed no significant association with an increased risk of hypertension.
  • Sensitivity analyses confirmed the robustness of the null findings.

Conclusions:

  • This study provides evidence against a direct causal link between hypertension and schizophrenia.
  • The findings suggest that observed associations may be due to other factors, not direct causation.
  • Further research may explore shared genetic or environmental factors contributing to both conditions.