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Updated: Jan 9, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Effects of fatty acids and their monoglycerides on aging, structural characteristics, and thermal stability of
Yandu Jiang1, Tongtong Mi1, Zijie Liu1
1Shandong Key Laboratory of Healthy Food Resources Exploration and Creation, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan, Shandong, 250353, China.
Abstract:
In this study, the mechanism by which fatty acids (lauric acid: LA and stearic acid: SA) and their monoglycerides (glycerol monolaurate: GML and glycerol monostearate: GMS) affect the functional properties of starch-based straws was investigated. X-ray diffraction analysis demonstrated that LA and its monoglyceride (GML) preferentially inserted into amylose helical cavities via hydrophobic interaction, forming structurally ordered V-type crystalline complexes. Fourier transform infrared spectroscopy measurement revealed that the 1047/1022 cm-1 and 995/1022 cm-1 ratio values of starch-based straws with lipids were lower than that of control group. When GML was added at 2 % concentration, the water contact angle increased by 34.76 %, and the bending modulus after 21 days of storage was maintained at 2.456 N/cm, which was significantly lower than the control (31.724 N/cm). Scanning electron microscopy analysis indicated that the GML2% sample exhibited a smoother surface with few protrusions. Thermogravimetric analysis showed that the lipid-containing samples (313.94 °C-317.24 °C) had a higher decomposition temperature than that of control (313.84 °C). In addition, Avrami kinetic modeling demonstrated that the incorporation of lipids reduced in the retrogradation rate constant (k). The anti-aging ability of the analyzed straws was in the following order: GML > LA > GMS > SA > control.
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