Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotaxis in E. coli01:27

Chemotaxis in E. coli

649
Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
649
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

4.3K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.3K
Cell Migration01:09

Cell Migration

18.5K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.5K
Anaphase A and B01:39

Anaphase A and B

5.3K
Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
5.3K
Capillary Electrophoresis: Applications01:30

Capillary Electrophoresis: Applications

1.1K
Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
1.1K
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

4.3K
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pattern Formation Beyond Turing: Physical Principles of Mass-Conserving Reaction-Diffusion Systems.

Annual review of biophysics·2026
Same author

Coarsening dynamics of chemotactic aggregates.

Physical review. E·2025
Same author

Delay-facilitated self-assembly in compartmentalized systems.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Robust and resource-optimal dynamic pattern formation of Min proteins in vivo.

Nature physics·2025
Same author

Basic interactions responsible for thymus function explain the convoluted medulla shape.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Availability versus carrying capacity: Phases of asymmetric exclusion processes competing for finite pools of resources.

Physical review. E·2025
Same journal

Erratum: Bacterial Turbulence at Compressible Fluid Interfaces [Phys. Rev. Lett. 136, 138301 (2026)].

Physical review letters·2026
Same journal

Unveiling Light-Quark Yukawa Flavor Structure via Dihadron Fragmentation at Lepton Colliders.

Physical review letters·2026
Same journal

Adaptable Route to Fast Coherent State Transport via Bang-Bang-Bang Protocols.

Physical review letters·2026
Same journal

Topological Transition and Emergence of Elasticity of Dislocation in Skyrmion Lattice: Beyond Kittel's Magnetic-Polar Analogy.

Physical review letters·2026
Same journal

Pound-Drever-Hall Method for Superconducting-Qubit Readout.

Physical review letters·2026
Same journal

Coupling a ^{73}Ge Nuclear Spin to an Electrostatically Defined Quantum Dot in Silicon.

Physical review letters·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

10.5K

Chemotaxis-Induced Phase Separation.

Henrik Weyer1, David Muramatsu1, Erwin Frey1,2

  • 1Ludwig-Maximilians-Universität München, Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Theresienstraße 37, D-80333 München, Germany.

Physical Review Letters
|November 30, 2025
PubMed
Summary
This summary is machine-generated.

Cellular self-organization via chemotaxis, explained by Keller-Segel models, is further detailed by a generalized Maxwell construction. This framework reveals how cell growth and death influence aggregate dynamics, linking chemotaxis to phase separation and reaction-diffusion patterns.

More Related Videos

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
10:40

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

Published on: November 9, 2017

7.3K
A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients
09:28

A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients

Published on: April 19, 2010

12.6K

Related Experiment Videos

Last Updated: Jan 9, 2026

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

10.5K
Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
10:40

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

Published on: November 9, 2017

7.3K
A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients
09:28

A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients

Published on: April 19, 2010

12.6K

Area of Science:

  • Mathematical Biology
  • Cellular Dynamics
  • Biophysics

Background:

  • Chemotaxis enables single-cell self-organization into populations, a phenomenon modeled by Keller-Segel equations.
  • Understanding the dynamics of these self-organizing systems is crucial for fields ranging from developmental biology to disease modeling.

Purpose of the Study:

  • To provide a generalized theoretical framework for chemotactic aggregation.
  • To link chemotactic self-organization with principles of phase separation and reaction-diffusion systems.
  • To elucidate the impact of cell growth and death on aggregate formation and stability.

Main Methods:

  • Application of a generalized Maxwell construction to model density fluxes and reactive turnover.
  • Analysis of how cell growth and death modify aggregate dynamics.
  • Connecting the framework to established concepts in phase separation and reaction-diffusion theory.

Main Results:

  • Chemotactic aggregation can be described by a balance of density fluxes and reactive turnover.
  • Aggregates typically exhibit coarsening dynamics.
  • Cell growth and death interrupt and reverse coarsening, leading to stable or dynamic aggregates.
  • The theory mechanistically connects chemotaxis to phase separation and reaction-diffusion patterns.

Conclusions:

  • A generalized Maxwell construction provides a unified view of chemotactic aggregation.
  • Cellular processes like growth and death play a critical role in determining the stability and dynamics of self-organized structures.
  • This work bridges the understanding of chemotaxis with broader concepts in physical and chemical pattern formation.