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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

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Published on: January 26, 2016

The Sources, Synthesis, and Applications of Cyclopeptides.

Wenxiu Ding¹, Xiao Wang¹, Jingwen Tian¹

¹Shandong Provincial Key Laboratory for the Discovery and Delivery of Natural Active Molecules, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, P. R. China.

Macromolecular Bioscience

|November 30, 2025

Summary

Cyclic peptides offer remarkable stability and selectivity, driving innovation in medicinal chemistry and materials science. This review details their natural sources, synthesis methods, and diverse applications in drug development and beyond.

Keywords:

cyclic peptides non‐peptide bond cyclization synthesis

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Area of Science:

Medicinal Chemistry
Materials Science
Biotechnology

Background:

Cyclic peptides are constrained molecules with significant stability, selectivity, and biological activity.
They are increasingly important in medicinal chemistry and materials science research.
Natural cyclic peptides are found in plants, microorganisms, and marine organisms, exhibiting diverse structures and pharmacological potential.

Purpose of the Study:

To systematically review the sources, synthetic strategies, and applications of cyclic peptides.
To provide a theoretical basis for structural optimization and functional design of cyclic peptides.
To highlight the multidisciplinary prospects of cyclic peptides.

Main Methods:

Systematic literature review of natural cyclic peptide sources.
Analysis of chemical synthesis strategies including head-to-tail and side-chain cyclization.
Review of non-peptide bond formation methods (disulfide, thioether, ester, C-C, click chemistry).

Main Results:

Detailed summary of natural cyclic peptide distribution and representative molecules.
Comparison of various synthesis approaches regarding efficiency and conformational control.
Outline of recent advancements in cyclic peptide applications across drug development, materials, food science, and diagnostics.

Conclusions:

Cyclic peptides possess extensive prospects in multidisciplinary research due to their unique properties.
Understanding their sources and synthesis is crucial for optimizing their structure and function.
This review serves as a valuable reference for future research and development in cyclic peptide applications.