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Advances in Fluorescence/Colorimetric Dual-Signal Sensors Enabled by Diverse Signal Activation Mechanisms
Haorun Song1, Mingyu Li2, Haotian Bai2
1Department of Chemistry, Beijing Technology and Business University, Beijing, China.
Luminescence : the Journal of Biological and Chemical Luminescence
|December 1, 2025
Summary
Dual-signal sensors combine fluorescence and colorimetric outputs for enhanced sensitivity and accuracy. This review explores their design and activation strategies for next-generation sensing technologies.
Area of Science:
- Analytical Chemistry
- Materials Science
- Sensor Technology
Background:
- Conventional single-signal sensors face limitations in sensitivity, detection range, and accuracy.
- Growing demand for advanced sensing technologies necessitates novel, portable, and cost-effective solutions.
- Dual-signal sensors integrate multiple detection modalities to overcome single-signal limitations.
Purpose of the Study:
- To review signal activation strategies and design principles for fluorescence/colorimetric dual-signal sensors.
- To highlight specific recognition mechanisms for diverse targets in dual-signal sensing.
- To provide insights for developing next-generation sensors with improved performance.
Main Methods:
- Review of recent advancements in fluorescence/colorimetric dual-signal sensor technology.
- Analysis of signal activation strategies and synergistic effects.
- Examination of target recognition mechanisms and sensor design principles.
Main Results:
- Fluorescence/colorimetric dual-signal sensors offer enhanced detection accuracy, broader ranges, and improved flexibility.
- Synergistic integration of optical signals significantly boosts detection efficiency.
- Diverse targets can be effectively recognized through specific design and activation strategies.
Conclusions:
- Dual-signal sensors represent a significant advancement over conventional single-signal systems.
- Optimized signal activation and recognition mechanisms are key to next-generation sensor design.
- These sensors hold great promise for applications in food safety, environmental monitoring, and biomedical fields.

