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Updated: May 3, 2026
Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Cutaneous Metastasis from Renal Cell Carcinoma: A Case Report
Reem Brashi1, Murooj Alotaibi2, Rehab Fadag3
1Department of Dermatology, First Health cluster, Riyadh, Saudi Arabia.
Introduction:
Cutaneous metastases from renal cell carcinoma (RCC) are an uncommon and poorly understood clinical phenomenon that frequently predicts a poor prognosis.
Case Presentation:
A 69-year-old male with a history of type 2 diabetes and benign prostatic hyperplasia was diagnosed with stage 4 RCC and various cutaneous lesions. A dermatological checkup during his hospitalization revealed asymptomatic subcutaneous nodules and purpuric areas. Biopsy and immunohistochemistry (IHC) staining confirmed the presence of cutaneous metastatic carcinoma, which is consistent with renal cell origin. The immunohistochemistry profile was positive for pancytokeratin, CD10, and vimentin but negative for PAX8, indicating a distinct appearance in RCC patients.
Conclusions:
This case emphasizes the necessity of recognizing cutaneous metastases as an uncommon presentation of advanced RCC, as well as PAX8's potential role as a diagnostic marker.
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