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Updated: Jan 9, 2026
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Clinical features analysis for complications in infants with late-onset Group B streptococcal sepsis: a retrospective
Haifeng Geng1, Wenqiang Sun1, Qiuping Shen1
1Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Insights
High PELOD-2 and pSOFA scores, elevated creatinine, and hypoalbuminemia are key risk factors for complications in late-onset Group B Streptococcal (GBS) sepsis infants. Early identification aids in risk stratification and tailored interventions for better outcomes.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Pediatric Critical Care
Background:
- Late-onset Group B Streptococcal (GBS) sepsis poses a significant threat to infants, often leading to severe complications.
- Identifying early risk factors is crucial for timely intervention and improved patient outcomes.
Purpose of the Study:
- To investigate risk factors associated with complications in infants diagnosed with late-onset GBS sepsis.
- To provide evidence-based insights for clinical intervention strategies.
Main Methods:
- Retrospective case-control study analyzing clinical data of 101 infants with late-onset GBS sepsis.
- Infants were categorized into complication and non-complication groups for comparative analysis.
- Univariate, multivariate analyses, and ROC curves were employed to identify risk factors and assess predictive efficacy.
Main Results:
- Infants with complications had lower gestational age, higher incidence of seizures, fever, and bulging fontanelle.
- Laboratory findings indicated hypoalbuminemia, elevated creatinine and BUN, and lower pH in the complication group.
- High PELOD-2 and pSOFA scores, elevated creatinine, and hypoalbuminemia were identified as significant risk factors (AUC=0.858).
Conclusions:
- High PELOD-2 score, high pSOFA score, elevated creatinine levels, and hypoalbuminemia are independent predictors of complications in late-onset GBS sepsis.
- These findings enable early risk stratification and personalized treatment approaches for affected infants.
Objective:
To investigate the risk factors associated with complications in infants with late-onset Group B Streptococcal (GBS) sepsis, and to provide evidence for clinical intervention strategies.
Methods:
This study is a retrospective case-control study. The clinical data of 101 infants with late-onset GBS sepsis, diagnosed before 3 months of age were retrospectively analyzed. According to the presence or absence of complications, the infants were divided into the complication group and the non-complication group. Univariate and multivariate analyses were performed to explore the risk factors associated with the occurrence of complications in infants with late-onset GBS sepsis. Using ROC curves to evaluate the predictive efficacy of clinical variables.
Results:
A total of 101 cases of late-onset GBS sepsis met the inclusion criteria, including 41 in the non-complication group and 60 in the complication group. The gestational age in the complication group was significantly lower than that in the non-complication group (P < 0.05). Clinically, the complication group had a higher incidence of seizure, bulging anterior fontanelle, and fever, as well as a significantly lower PaO2/FiO2 ratio (P < 0.05). Laboratory findings showed that the complication group had a higher incidence of hypoalbuminemia, concomitant positivity in blood and cerebrospinal fluid cultures, elevated creatinine and blood urea nitrogen levels, and significantly lower pH and albumin levels (P < 0.05). In addition, the complication group exhibited significantly higher Pediatric Sequential Organ Failure Assessment (pSOFA) scores, Pediatric Logistic Organ Dysfunction Score 2 (PELOD-2) scores, and higher proportion of patients with high pSOFA (>3.50) and PELOD-2 scores (>3.50) (P < 0.05). Multivariate analysis revealed that high PELOD-2 score, high pSOFA score, high creatinine levels and hypoalbuminemia were risk factors for the development of complications in infants with late-onset GBS sepsis; the ROC curve constructed using these predictors demonstrated excellent discriminative ability, with an AUC of 0.858 (95% CI: 0.782-0.934), sensitivity of 77.78%, and specificity of 82.61%.
Conclusion:
High PELOD-2 score, high pSOFA score, high creatinine levels, and hypoalbuminemia independently predict complications in late-onset GBS sepsis infants, enabling early risk stratification and tailored treatment to improve outcomes.
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