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Genetic engineering frontiers in cell manipulation-based tissue engineering: A comprehensive review.

Amirhossein Mohammadi1, Mohammad Ali Heydari1, Zahra Jamalpoor1

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Genetic engineering combined with tissue engineering is revolutionizing regenerative medicine by creating functional tissue replacements. This synergy enhances engineered tissues for various applications, offering new hope for unmet medical needs.

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Genetics

Background:

  • The growing demand for functional tissue replacements necessitates advanced solutions.
  • Tissue engineering and genetic engineering offer synergistic opportunities.

Purpose of the Study:

  • To review cutting-edge cell manipulation-based tissue engineering approaches through the lens of genetic engineering.
  • To highlight the transformative potential of combining these fields.

Main Methods:

  • Examination of advanced genetic engineering techniques (CRISPR-Cas9, TALENs, synthetic biology) for cell modification.
  • Review of diverse engineered tissues (cartilage, bone, cardiac, neural, skin, vascular).
  • Investigation of integration with 3D-bioprinting, microfluidics, and smart biomaterials.

Main Results:

  • Genetic manipulation enhances functionality and physiological relevance of engineered tissues.
  • Pioneering trends include in vivo regeneration and patient-specific tissues.
  • Emerging technologies like base editing and synthetic circuits enable "smart" tissues.

Conclusions:

  • Genetic engineering significantly impacts cell manipulation-based tissue engineering.
  • Challenges include genetic stability, scalability, and ethical considerations.
  • Advancements promise genetically tailored tissues for regenerative medicine.