Related Experiment Video
Updated: Jul 4, 2026
12:22
A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput
Published on: September 22, 2019
8.9K
Paths towards commercialization: evidence from NIH proof of concept centers
Adams G Bailey1, Breanna M Reingold1, Joseph D Johnson1
1RTI International, Durham, USA.
The Journal of Technology Transfer
|December 1, 2025
Summary
Proof of Concept Centers (PoCCs) aid academic innovators in commercializing biomedical technologies. Greater PoCC support correlates with more licensing agreements, indicating their effectiveness in driving commercialization success.
Area of Science:
- Biomedical technology commercialization
- Academic innovation and technology transfer
Background:
- Proof of Concept Centers (PoCCs) are crucial for academic commercialization.
- Limited evidence exists on PoCC effectiveness, particularly in life sciences.
- Understanding factors influencing PoCC project success is vital.
Purpose of the Study:
- To investigate how Principal Investigator (PI) and technology characteristics affect PoCC strategies.
- To analyze the impact of PoCC support levels on commercialization outcomes.
- To identify determinants of project trajectories within PoCCs.
Main Methods:
- Analysis of a unique dataset tracking 275 NIH-funded biomedical technologies (NCAI and REACH).
- Examination of PI characteristics (gender, experience, title) and technology types.
- Correlation of PoCC support levels with commercialization activities, specifically licensing agreements.
Main Results:
- PI characteristics and technology type influence PoCC priorities and strategies.
- Increased PoCC support is empirically linked to a higher frequency of licensing agreements.
- Evidence suggests varied commercialization trajectories based on project and PI factors.
Conclusions:
- PoCCs play a significant role in promoting biomedical technology commercialization.
- PI and technology attributes are key determinants of PoCC project strategies and outcomes.
- PoCC support levels directly impact the rate of successful technology licensing.
Related Concept Videos
01:16Clinical Trials
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
01:26Drug Discovery: Overview
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
01:11Clinical Trials: Overview
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
01:28Preclinical Development: Overview
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
01:29Clinically Relevant Drug Product Specifications: Methods of Establishment
Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...