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Updated: Jan 9, 2026

Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution
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The advances of DEAD-box RNA helicase 17 in chronic non-infectious diseases

Mi Xiong1, Qiang Wang1, Ting Wang1

  • 1Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.

Frontiers in Cardiovascular Medicine
|December 1, 2025
PubMed

Insights

DEAD-box RNA helicase 17 (DDX17) is crucial for cell functions, regulating RNA metabolism and impacting diseases like cancer and cardiovascular disorders. Understanding DDX17 offers insights into biological processes and potential clinical applications.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • DEAD-box RNA helicase 17 (DDX17) is a key protein involved in fundamental cellular processes.
  • It exhibits conserved structural features, including a DEAD-box domain responsible for RNA-dependent ATPase and helicase activities.
  • DDX17 exists as p72 and p82 isoforms and is found in both nuclear and cytoplasmic compartments.

Purpose of the Study:

  • To provide a comprehensive review of DDX17.
  • To summarize its structural characteristics, cellular distribution, and diverse biological functions.
  • To explore its associations with various chronic non-infectious diseases and current research trends.

Main Methods:

  • Literature review and synthesis of existing research on DDX17.
  • Analysis of structural, functional, and disease-related data from published studies.
  • Identification of key pathways and research trends involving DDX17.

Main Results:

  • DDX17 possesses RNA-dependent ATPase and helicase activities, with distinct isoforms (p72/p82).
  • It is highly expressed in cardiomyocytes and neuronal tissues, localizing to the nucleus and cytoplasm.
  • DDX17 plays roles in RNA metabolism, DNA repair, protein interactions, tumor progression (e.g., Wnt/β-catenin pathway), cardiovascular health, and neurological disorders.

Conclusions:

  • DDX17 is a multifunctional protein with significant implications in cellular physiology.
  • Its involvement in diverse diseases highlights its potential as a therapeutic target.
  • Further research into DDX17's functions and clinical applications is warranted.
Keywords:
DDX17cardiovascular diseaseschronic non-infectious diseasesfunctionstructuretumors

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