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Measurement of 227Ac by Isotopic Ratio with 225Ac Using ICP-MS.

Jakob E Baumeister1, Benjamin W Puffer1, Cory A Hawkins1

  • 1NorthStar Medical Radioisotopes, LLC, 1800 Gateway Blvd., Beloit, Wisconsin 53511, United States.

ACS Omega
|December 1, 2025
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A new method accurately measures Actinium-227 (227Ac) in Actinium-225 (225Ac) active pharmaceutical ingredients (APIs) using ICP-MS. This rapid, sensitive technique ensures quality testing and regulatory compliance for 225Ac APIs.

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Area of Science:

  • Radiochemistry
  • Analytical Chemistry
  • Nuclear Medicine

Background:

  • Actinium-225 (225Ac) is a critical therapeutic radionuclide.
  • Ensuring the radioisotopic purity of 225Ac API is essential for patient safety and treatment efficacy.
  • Existing methods for quantifying Actinium-227 (227Ac) impurity in 225Ac API are time-consuming.

Purpose of the Study:

  • To develop and validate a rapid, accurate, and sensitive method for measuring 227Ac in 225Ac API.
  • To provide a method suitable for routine quality control testing of 225Ac API.
  • To enable accurate reporting of 227Ac content for regulatory compliance.

Main Methods:

  • Inductively coupled plasma mass spectrometry (ICP-MS) combined with isotope ratio analysis.
  • Direct measurement of the 225Ac/227Ac isotope ratio from ICP-MS count rate data.
  • Conversion of isotope ratio to activity ratio using nuclear decay equations, coupled with orthogonal 225Ac activity measurement.

Main Results:

  • The method demonstrated linearity, accuracy (spike recoveries 74-108%), and precision (4.1% intermediate precision).
  • Instrumental detection limits for 227Ac were as low as 23 Bq L-1.
  • Analysis time is as short as 2 hours with simple sample preparation (dilution in acid).

Conclusions:

  • The developed ICP-MS method provides a rapid, accurate, and sensitive means to quantify 227Ac in 225Ac API.
  • This method is advantageous over traditional radiometric techniques, offering faster results for quality testing.
  • Implementation of this method supports 225Ac API producers and end-users in ensuring product quality and regulatory adherence.