Temporal trends and demographic-geographic disparities in kidney Cancer mortality in the United States, 1999-2023

Objective: To analyze temporal trends and disparities in kidney cancer mortality in the United States (1999-2023) by demographics, geography, and urbanization, using data from the Centers for Disease Control and Prevention (CDC) WONDER database. Methods: Death data were extracted from the CDC Wonder database covering the United States during the period 1999-2023 and analyzed via Joinpoint regression and spatial analysis. Results: In 1999-2023, kidney cancer deaths increased by 33.38 % (from 10,862 to 14,488), while the age-adjusted mortality rate (AAMR) declined significantly (average annual percentage change (AAPC) = -0.76 %) in the United States. By age, 35-44 and 45-54-year-olds had the sharpest AAMR drops (annual percentage change (APC) = -1.81 and - 1.92, respectively); ≥75-year-olds rose, with the 85+ group's unadjusted mortality increasing annually (AAPC = 0.58 %). By sex, women's AAMR fell steadily (2005-2023 APC = -1.65), while men's stagnated after 2018. By race, Hispanics (AAPC = -0.76 %) and non-Hispanic Blacks (AAPC = -1.33 %) declined; non-Hispanic Whites stabilized later. Geographically, the Midwest showed "rise-fall-accelerated decline-stagnation" fluctuation, the West dropped steadily (AAPC = -0.91 %); metropolitan areas fell faster (2012-2020 APC = -1.97) than non-metros (AAPC = -0.39 %). Conclusion: In the United States, kidney cancer mortality declined overall but with significant disparities, requiring targeted interventions.