Rocuronium for Treatment of Sugammadex Anaphylaxis: A Case Report.

Area of Science:

• Anesthesiology
• Critical Care Medicine
• Immunology

Background:

• Intraoperative anaphylaxis is a rare but life-threatening emergency.
• Rocuronium is a frequent cause of anaphylaxis during surgery.
• Sugammadex is a reversal agent for rocuronium, but can itself cause anaphylaxis.

Purpose of the Study:

• To present a case of refractory anaphylaxis potentially triggered by sugammadex.
• To investigate the efficacy of rocuronium in treating sugammadex-induced anaphylaxis.

Main Methods:

• Case report of a critically ill patient experiencing refractory anaphylaxis.
• Administration of rocuronium to manage suspected sugammadex-induced anaphylaxis.

Main Results:

• The patient presented with refractory anaphylaxis, suspected to be caused by sugammadex.
• Rocuronium administration rapidly stabilized the patient's hemodynamics.
• This suggests a potential therapeutic role for rocuronium in sugammadex-induced anaphylaxis.

Conclusions:

• Sugammadex-induced anaphylaxis can be refractory to standard treatment.
• Rocuronium may be an effective treatment for sugammadex-induced anaphylaxis.
• This finding challenges the typical understanding of these agents in anaphylaxis management.