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Deploying an FcMBL-Based Extracorporeal Blood Purification Filter in a Critically Ill Patient with COVID-19
Conor Higgins1, Samuel Ostrowski2, Linda Barr3
1T.H. Chan School of Medicine at the University of Massachusetts, Worcester, MA, USA.
This study reports the first clinical use of an extracorporeal filter with FcMBL protein to remove SARS-CoV-2 and pathogen-associated molecular patterns (PAMPs) from a critically ill COVID-19 patient, showing feasibility for reducing pathogen load.
Area of Science:
- Immunology
- Virology
- Critical Care Medicine
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, leading to multiorgan failure and mortality.
- Circulating SARS-CoV-2 levels correlate with disease severity and patient outcomes.
- Pathogen-associated molecular patterns (PAMPs) contribute to severe infections.
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