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Sequential Diagnosis of Metastatic Breast Cancer and Follicular Lymphoma in a Postmenopausal Woman: Navigating
Hye Sook Kim1, Sunhee Chang2, Jae Il Kim3
1Division of Hematology-Oncology, Department of Internal Medicine, Inje University Ilsan Hospital, Goyang, Republic of Korea.
Introduction:
Dual primary malignancies involving solid and hematologic tumors are rare, posing significant diagnostic and therapeutic challenges. We report here a case of concurrent breast cancer and follicular lymphoma.
Case Presentation:
A 52-year-old woman with hormone receptor-positive early-stage breast cancer (pT2N2a) developed pleural metastasis concurrently with newly diagnosed follicular lymphoma (Ann Arbor stage IIIA, grades 1-2) at 3 years post-diagnosis. The lymphoma progressed during treatment for metastatic breast cancer. Consequently, the treatment was switched to combination immunochemotherapy with rituximab, cyclophosphamide, vincristine, and prednisolone (R-CVP). The patient achieved a partial response for follicular lymphoma, without breast cancer progression. Endocrine therapy with letrozole and palbociclib was successfully resumed following bone marrow recovery.
Conclusion:
This case highlights the need to consider secondary malignancies during cancer treatment and demonstrates the clinical utility of R-CVP in the management of dual cancer.
