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Rare Primary Hepatic Mucoepidermoid Carcinoma: A Report of Two Cases
Yalan Huang1, Xuan Luo1, Baian Lai1
1Department of Pathology, Suining Central Hospital, Suining, China.
Introduction:
Primary mucoepidermoid carcinoma (MEC) of the liver is an extremely rare malignant tumor with nonspecific symptoms and signs.
Case Presentation:
The 2 cases included one Chinese male and one Chinese female, aged 72 and 47 years, respectively. Their clinical manifestations were hematemesis and upper abdominal pain. Imaging features were atypical, showing heterogeneous enhancement or cystic areas. After surgical resection, the pathological diagnosis was hepatic MEC, and the CRTC1-MAML2 fusion gene was found. Both patients did not undergo radiotherapy and chemotherapy after the operation, and died of tumor metastasis 3-4 months after tumor resection.
Conclusion:
Hepatic MEC is rare and has an extremely poor prognosis. Surgical resection is the main treatment, and diagnosis requires confirmation through histopathology, immunohistochemistry, and special staining. CRTC1-MAML2 fusion can also assist in diagnosis.
