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Hereditary angioedema: A national investigation of associated comorbidities and surgical procedures

Lili Voloncs-Mindszenthy1, Hanga Réka Horváth1, Noémi Andrási1,2,3

  • 1Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.

The World Allergy Organization Journal
|December 1, 2025
PubMed

Insights

Hereditary angioedema (HAE-C1INH) patients have more comorbidities like hypercholesterolemia and hypertension. Early HAE diagnosis can prevent unnecessary surgeries, highlighting the need for targeted screening.

Area of Science:

  • Immunology
  • Genetics
  • Internal Medicine

Background:

  • Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH) involves recurrent swelling attacks.
  • C1 inhibitor deficiency disrupts enzyme regulation, potentially leading to comorbidities.

Purpose of the Study:

  • To investigate comorbidities in Hungarian HAE-C1INH patients.
  • To analyze surgical procedures in this population.
  • To compare findings with the general Hungarian population.

Main Methods:

  • Retrospective analysis of data from 178 adult HAE-C1INH patients.
  • Inclusion of demographic, clinical, laboratory, and radiographic data.
  • Comparison with national and European statistical data.

Main Results:

  • 159 out of 178 patients had at least one comorbidity.
  • Most common comorbidities: headache (58%), hypercholesterolemia (52%), hypertension (30%), liver diseases (26%).
  • Hypercholesterolemia and depression/anxiety were over 3 times more frequent in HAE-C1INH patients.
  • Surgical procedures like tonsillectomy and appendectomy were more prevalent before HAE diagnosis.

Conclusions:

  • Targeted screening is crucial for early detection of prevalent diseases in HAE-C1INH patients.
  • Timely angioedema attack management can prevent unnecessary surgeries.
Abstract

Keywords:
C1-inhibitor deficiencyComorbidityHereditary angioedemaSurgical procedures

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