Multifocal tenosynovial giant cell tumor: A case report
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Updated: Sep 28, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Mohammed M Kanani1, Sara Haseli2, Majid Chalian2
1School of Medicine, University of Washington, UW Medical Center at 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Abstract:
Tenosynovial giant cell tumor is a rare, generally benign soft tissue lesion arising from the synovial lining of joints, bursae, or tendon sheaths. It most commonly presents as a solitary, localized mass in the small joints of the hands and feet. Diagnosis can be difficult due to clinical overlap with other soft tissue masses. Imaging and histopathologic confirmation are critical for diagnosis, while management decisions are guided by considerations of tumor extent, symptom burden, and patient preference, with close follow-up to monitor progression. Surgical excision remains the standard treatment; however, observation may be appropriate in select cases with minimal functional impairment. This case illustrates a rare presentation in a 56-year-old male with multifocal involvement of noncontiguous digits and highlights the importance of clinical awareness of unusual presentations and supporting individualized treatment planning.
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