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Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
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Correction: Case Report: Unraveling complex genomic alterations in a case of chronic lymphocytic leukemia using

Leila Youssefian1, Sahoo Trilochan2, Jia-Chi Wang1

  • 1Cytogenetics Laboratory, City of Hope National Medical Center, Irwindale, CA, United States.

Frontiers in Oncology
|December 1, 2025
PubMed

Abstract:

[This corrects the article DOI: 10.3389/fonc.2025.1639849.].

Keywords:
cancer cytogeneticschromothripsis and chomoplexychronic lymphocytic leukemia (CLL)complex karyotype (CK)fluorescence in situ hybridization (FISH)genome instabilityoptical genome mapping (OGM)structural variants (SV)

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Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...

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