Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Tumor Progression02:07

Tumor Progression

7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spleen-targeted neoantigen mRNA vaccine induces ISG15<sup>+</sup> CD8<sup>+</sup> T cell-mediated tertiary lymphoid structure formation in hepatocellular carcinoma.

Cell reports. Medicine·2026
Same author

Hybrid experimental-machine learning framework for media optimization enhances antioxidant production in Micrococcus endophyticus SS-1.

Journal of microbiological methods·2026
Same author

Neoantigens and shared MICB α3 antigen dual-targeted vaccine generates potent antitumor immunity.

EMBO molecular medicine·2026
Same author

Corrigendum to "Enhanced underwater adhesion of chitooligosaccharide-based pressure-sensitive adhesives and their potential in wound healing applications" [Carbohydrate Polymers 368 (2025) 124227].

Carbohydrate polymers·2026
Same author

Residential greenness and atopic dermatitis in Japanese children: Findings from the TMM BirThree cohort study.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Meta-path and context-aware learning for attribute completion in heterogeneous graphs.

Neural networks : the official journal of the International Neural Network Society·2026

Related Experiment Video

Updated: Jan 9, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.2K

Involvement of TP53 in osteosarcoma - challenges and prospects.

Yue Shen1, Shuzhou Huang2, Geng Chen1

  • 1Binzhou Medical University, Yantai, Shandong, China.

Frontiers in Oncology
|December 1, 2025
PubMed
Summary

Mutations in the TP53 gene drive osteosarcoma progression and resistance to therapy. Targeting mutant TP53 and associated pathways offers new strategies to improve patient outcomes.

Keywords:
TP53molecular mechanismmutationosteosarcomap53

More Related Videos

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

9.2K
Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study
02:35

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Published on: March 22, 2024

1.4K

Related Experiment Videos

Last Updated: Jan 9, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.2K
Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

9.2K
Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study
02:35

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Published on: March 22, 2024

1.4K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Osteosarcoma (OS) is the most common primary bone cancer, characterized by high metastatic potential, chemoresistance, and poor prognosis.
  • Mutations in the TP53 tumor suppressor gene are critical drivers of OS progression, affecting cell cycle, DNA repair, apoptosis, immune evasion, and metabolism.

Purpose of the Study:

  • To provide an in-depth analysis of p53 biology in osteosarcoma.
  • To highlight the impact of TP53 mutations on therapeutic resistance and tumor progression.
  • To discuss novel therapeutic strategies targeting mutant TP53 and related pathways.

Main Methods:

  • Comprehensive review of existing literature on p53 in osteosarcoma.
  • Analysis of the role of TP53 mutations in OS pathogenesis.
  • Exploration of current and emerging therapeutic approaches, including radiotherapy, chemotherapy, immunotherapy, metabolic reprogramming, noncoding RNA regulation, and precision biomarkers.

Main Results:

  • TP53 mutations significantly influence OS progression and therapeutic response.
  • Targeting mutant TP53 and its downstream pathways presents a promising therapeutic avenue.
  • Emerging strategies like metabolic reprogramming and precision biomarkers show potential for improved diagnosis and treatment.

Conclusions:

  • Understanding p53 biology is crucial for developing effective osteosarcoma treatments.
  • Targeting mutant TP53 pathways and utilizing novel approaches can enhance therapeutic strategies.
  • Translational research linking molecular mechanisms to clinical applications is key to improving outcomes for osteosarcoma patients.