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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Jan 9, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
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Dermatofibrosarcoma Protuberans in Children: Favorable Outcomes Using Wide Local Excision.

Jawad Aqeel1, Claire E Holtz2, Grace A Osborne3

  • 1Department of Dermatology, Division of Cutaneous Surgery and Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Pediatric Dermatology
|December 1, 2025
PubMed
Summary
This summary is machine-generated.

Wide local excision (WLE) is effective for pediatric dermatofibrosarcoma protuberans (DFSP). This treatment, even with narrow margins, shows excellent survival and low recurrence rates in children.

Keywords:
dermatofibrosarcoma protuberansmarginspediatric dermatologywide local excision

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Area of Science:

  • Pediatric Oncology
  • Surgical Oncology
  • Dermatopathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, aggressive skin cancer.
  • Pediatric DFSP lacks specific treatment guidelines.
  • Wide local excision (WLE) is the primary treatment for DFSP.

Purpose of the Study:

  • To evaluate outcomes of WLE in pediatric DFSP patients.
  • To inform pediatric-specific DFSP management strategies.
  • To analyze recurrence and survival rates after WLE.

Main Methods:

  • Retrospective review of 17 pediatric DFSP patients treated with WLE (2004-2024).
  • Comparison of outcomes based on surgical margin width (<2 cm vs. ≥2 cm).
  • Descriptive analysis of patient data and treatment results.

Main Results:

  • Complete excision achieved in 76.5% of patients with margins ≤2 cm.
  • No local or distant recurrence observed; no adjuvant therapy needed.
  • 100% 5-year recurrence-free, disease-specific, and overall survival rates.

Conclusions:

  • WLE with 1-2 cm margins is effective for pediatric DFSP.
  • Re-excision for clear margins does not compromise outcomes.
  • WLE is a viable treatment option for pediatric DFSP.